People with a family history of gastric
cancer can be tested by their doctor for H. pylori infection provided
those with a positive Helicobacter Pylori result will be treated.
Helicobacter Pylori result will be treated. However, screening people
with no symptoms of Helicobacter Pylori infections as a means of
reducing gastric cancer is not currently recommended.
What is Helicobacter Pylori ?
- Helicobacter Pylori (H. pylori) is a
spiral shaped bacterium that has probably been in existence for many
centuries.
- Helicobacter Pylori has the ability to
survive in the acid pH environment of the stomach, and the infection
causes inflammation of the stomach lining which play a part in
gastrointestinal diseases such as dyspepsia, gastric ulcers, gastric
cancer and duodenal ulcers.
How is Helicobacter Pylori linked to
gastric cancer ?
- There is considerable evidence suggesting
Helicobacter Pylori as a risk factor for the development of
gastric cancer. Research has shown people with Helicobacter Pylori have
nearly three times risk of gastric cancer.
- Countries with high rates of gastric
cancer also tend to have high levels of Helicobacter Pylori infection.
- Helicobacter Pylori is the only bacterium
that has been classified as a group I or definite, cancer-causing agent
(carcinogen) because of its association with gastric adenocarcinoma.
Why is Helicobacter Pylori so common in
Asia Pacific ?
- Helicobacter Pylori infection is likely
to be spread from person to person, by mouth.
- Eating practices in some Asia Pacific
countries may be implicated. Research has suggested the use of
chopsticks to pose a risk. Communal eating, sharing food from the same
bowls, and eating with hands may also be important ways in which
Helicobacter Pylori infection is spread.
- Densely packed living conditions, and
people living within proximity to one another is also thought to be a
factor for spreading Helicobacter Pylori.
How common is gastric cancer ?
- Gastric cancer is the second most common
type of cancer in the world, causing more than 750,000 deaths annually.
How can Helicobacter Pylori infection be
treated ?
- Helicobacter Pylori can be successfully
eradicated with triple therapy based on antibiotics plus an acid
blocker.
- Recent studies have shown eradication
rates of more than 90% with one week's treatment with acid blocker
omeprazole plus combinations of the antibiotics clarithromyin, and
either amoxicilin or metronidazole.
- Clarithromycin is the only antibiotic
recommended in all choices for first-line treatment regimes recommended
by the Asia Pacific Consensus.
- Once Helicobacter Pylori has been
eradicated in adults, recurrence is rare.
What is Dyspepsia, and how is it linked
to Helicobacter Pylori ?
- Dyspepsia (indigestion) is abdominal pain
or discomfort in the upper abdomen, often brought on by eating, which
persists for two weeks or longer, and is severe enough to cause the
sufferer to seek medical advice.
- Symptoms include heartburn, abdominal
pain, nausea and flatulence (excessive wind).
- The Helicobacter Pylori causes
inflammation of the stomach lining which plays a part in diseases such
as dyspepsia.
How can dyspepsia be treated ?
- Current treatments vary throughout Asia
Pacific depending on the availability of endoscopy (a technique which
involves looking into the stomach with a narrow tube).
- The consensus suggested three treatment
pathways (algorithms), depending on the prevalence of gastric cancer,
and access to procedures such as endoscopy.